M. A. Hussein, V. T. Huynh, R. Hommelsheim, R. M. Koenigs, T. V. Nguyen. Your Mendeley pairing has expired. Please reconnect. Get article recommendations from ACS based on references in your Mendeley library. Alkylation with Alcohols for the Synthesis of α-Alkylated Ketones. You’ve supercharged your research process with ACS and Mendeley! China. Enolizable alkyl phenyl ketones were found to react readily with ethyl trifuoroacetate under the promotion of NaH to afford trifluoroacetic ester/ketone exchange products, trifluoromethyl ketones, which were quite different from the general Claisen condensation products, β-diketones. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Li-Juan Xing, Tao Lu, Wei-Li Fu, Mei-Mei Lou, Bo Chen, Zhi-Shen Wang, Yang Jin, Dan Li, Bin Wang. α-Alkylation of Ketones with Primary Alcohols Catalyzed by a Cp*Ir Complex Bearing a Functional Bipyridonate Ligand. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Yilong Zhao, Yuhan Zhou, Juan Liu, Dongmei Yang, Liang Tao, Yang Liu, Xiaoliang Dong, Jianhui Liu, and Jingping Qu . The reaction is driven to product by the final deprotonation step. Mechanism; Condensation Types; An aldol condensation is a condensation reaction in organic chemistry in which an enol or an enolate ion reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone, followed by dehydration to give a conjugated enone.. Aldol condensations are important in organic synthesis, because they provide a good way to form … Crossed Claisen Condensation. The Claisen-Schmidt condensation is what happens when you have an enolizable aldehyde plus ketone. A Convergent Radical Based Route to Trifluoromethyl Ketones and to α,β-Unsaturated Trifluoromethyl Ketones. Synthesis of (Z)-α-Trifluoromethyl Alkenyl Triflate: A Scaffold for Diverse Trifluoromethylated Species. the merger of oxoammonium cations and photoredox catalysis. )–H functionalization of 2-methylazaarenes through direct benzylic addition to trifluoromethyl ketones. Dong Li, Yuhan Zhou, Yilong Zhao, Chunxia Zhang, Jianzhe Li, Jinfeng Zhao, Jingping Qu. Abderrahman El Bouakher, Ronan Le Goff, Jordan Tasserie, Jérôme Lhoste, Arnaud Martel, and Sébastien Comesse . http://pubs.acs.org/page/copyright/permissions.html, https://doi.org/10.1021/acs.orglett.6b00851, https://doi.org/10.1021/acs.orglett.5b01344, https://doi.org/10.1016/j.jfluchem.2018.05.013, https://doi.org/10.1016/j.jfluchem.2015.01.015, https://doi.org/10.1016/j.tet.2014.05.017. Find more information about Crossref citation counts. Three-Component Cascade Reaction. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. View the notice. This article has been corrected. Learn about our remote access options, State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China. via The resulting products are invariably cyclic 13-ketone derivatives. Information about how to use the RightsLink permission system can be found at The Claisen-Schmidt reaction is called the aldol condensation of ketones with aryl aldehydes into α,β-unsaturated derivatives. Working off-campus? Detrifluoroacetylation Reaction of Trifluoromethyl-β-diketones: Facile Method for the Synthesis of Succinimide Derivatives and 1,4-Diketones. The condensing bases may be sodium, sodium ethoxide, sodium hydride, potassium t-butoxide, etc. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Fengxiang Zhu, Guangfu Yang, Shaolin Zhou, Xiao-Feng Wu. http://pubs.acs.org/page/copyright/permissions.html. The Claisen condensation is the ester analogue of the Aldol condensation. Users are Pengcheng Liu, Ran Liang, Lei Lu, Zhentao Yu, and Feng Li . Application of N‐Acylimidazoles in the Claisen Condensation Reaction Haiyuan Quan State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China retro Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Please check your email for instructions on resetting your password. from the ACS website, either in whole or in part, in either machine-readable form or any other form The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Palladium-catalyzed geometrically selective hydrogenation of (Z)-trifluoromethyl alkenyl triflate: an efficient approach to (Z) or (E)-3,3,3-trifluoropropenyl derivatives. Use of a Cyclometalated Iridium(III) Complex Containing a N∧C∧N-Coordinating Terdentate Ligand as a Catalyst for the α-Alkylation of Ketones and N-Alkylation of Amines with Alcohols. not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information the Altmetric Attention Score and how the score is calculated. and you may need to create a new Wiley Online Library account. Synthesis of Oxazolidin-4-ones: Domino O-Alkylation/Aza-Michael/Intramolecular Retro-Claisen Condensation. Equilibrium in the Catalytic Condensation of Carboxylic Acids with Methyl Ketones to 1,3-Diketones and the Origin of the Reketonization Effect. Homo‐ and cross‐Claisen condensation reactions are usually carried out using a Ti(IV)‐based reagent at ultra‐low‐temperatures. Trifluoromethyl ketones: properties, preparation, and application.